Across TCGA cell cohorts, LMLN mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LMLN-associated genes across cancer lineages are IL31, GP9, and GPR88. Each is linked with LMLN in more than 1 cancer types. Because this analysis shows association rather than direction, both LMLN-to-partner and partner-to-LMLN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMLN→partner) and Y-score (partner→LMLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL31 →	+0.028	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GP9 →	+0.075	+4.196	.005	.002	3	1
LARGE_INTESTINE	GPR88 →	+0.011	+3.684	<.001	.006	3	1
BLOOD_Lymphoma	CCDC83 →	+0.044	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	IFIT1B →	+0.053	+4.070	<.001	.004	3	1
BLOOD_Leukemia	CACNG1 →	+0.122	+3.881	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

LMLN survival (RNA) · tumor vs normal (RNA) · all LMLN data types