LMF2

Across TCGA patient cohorts, LMF2 mutation is significantly associated with the RNA expression of many other genes, with 1,183 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMF2-associated genes across cancer lineages are SNRPD3, CRYBB2P1, and CENPM. Each is linked with LMF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMF2-to-partner and partner-to-LMF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD3 grouped by LMF2-low versus LMF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMF2→partner) and Y-score (partner→LMF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPD3 →	+0.414	+4.169	.001	<.001	3	2
UCEC	CRYBB2P1 →	+0.435	+1.928	.007	.009	3	2
COAD	CENPM →	+0.919	+3.584	<.001	.002	3	2
COAD	MCM5 →	+0.681	+3.509	<.001	.002	3	2
UCEC	BCCIP →	+0.412	+3.374	.007	.004	3	2
UCEC	YPEL5 →	-0.457	-3.807	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,183 associations by consensus.

SNRPD3 by LMF2 expression — UCEC

Explore this box plot interactively →