LMF2

Across TCGA cell cohorts, LMF2 mutation is significantly associated with the RNA expression of many other genes, with 222 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMF2-associated genes across cancer lineages are EN1, LANCL1, and KCNK4. Each is linked with LMF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMF2-to-partner and partner-to-LMF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EN1 grouped by LMF2-low versus LMF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMF2→partner) and Y-score (partner→LMF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EN1 →	+1.018	+3.758	<.001	.001	3	2
BLOOD_Leukemia	LANCL1 →	+0.722	+3.199	.005	.007	3	2
BLOOD_Leukemia	KCNK4 →	+0.150	+2.783	<.001	.001	3	2
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	NPHS2 →	+0.010	+4.321	<.001	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	C4orf45 →	+0.054	+3.917	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 222 associations by consensus.

EN1 by LMF2 expression — LARGE_INTESTINE

Explore this box plot interactively →