LMCD1

Across TCGA patient cohorts, LMCD1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LMCD1-associated genes across cancer lineages are Gab2, Akt, and Rab11. Each is linked with LMCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMCD1-to-partner and partner-to-LMCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by LMCD1-low versus LMCD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMCD1→partner) and Y-score (partner→LMCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Gab2 →	-0.409	-2.974	.015	.036	3	1
COAD	Akt →	-0.971	-2.991	<.001	.036	3	1
COAD	Rab11 →	+0.229	+3.025	.006	.019	3	1
COAD	Axl →	-0.484	-2.981	<.001	.036	3	1
UCEC	Rab25 →	-0.443	-3.169	.002	.018	3	1
UCEC	VHL →	-0.837	-3.459	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Gab2 by LMCD1 expression — COAD

Explore this box plot interactively →