LMCD1

Across TCGA cell cohorts, LMCD1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMCD1-associated genes across cancer lineages are CRX, TBC1D21, and OR4F5. Each is linked with LMCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMCD1-to-partner and partner-to-LMCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRX grouped by LMCD1-low versus LMCD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMCD1→partner) and Y-score (partner→LMCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRX →	+0.020	+3.347	.001	.005	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR4F5 →	+0.024	+3.345	<.001	.007	3	1
LARGE_INTESTINE	ARGFX →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PFN3 →	+0.122	+3.882	<.001	.001	3	1
LARGE_INTESTINE	MAGEB1 →	+0.187	+3.878	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CRX by LMCD1 expression — LARGE_INTESTINE

Explore this box plot interactively →