LMBRD2

Across TCGA cell cohorts, LMBRD2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LMBRD2-associated genes across cancer lineages are TTLL8, WFDC11, and GNG8. Each is linked with LMBRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMBRD2-to-partner and partner-to-LMBRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by LMBRD2-low versus LMBRD2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMBRD2→partner) and Y-score (partner→LMBRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TTLL8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	WFDC11 →	+0.046	+4.906	<.001	.006	3	1
BLOOD_Leukemia	GNG8 →	+1.010	+4.234	.004	.003	3	1
BLOOD_Leukemia	WFDC12 →	+0.198	+3.874	<.001	.005	3	1
BLOOD_Leukemia	DEFB4A →	+0.096	+4.269	.001	.002	3	1
BLOOD_Leukemia	MAGEB6 →	+0.364	+3.978	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TTLL8 by LMBRD2 expression — OESOPHAGUS

Explore this box plot interactively →