LMBRD1

Across TCGA patient cohorts, LMBRD1 mutation is significantly associated with the RNA expression of many other genes, with 1,833 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMBRD1-associated genes across cancer lineages are TYMS, MIR3619, and RNA5SP113. Each is linked with LMBRD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LMBRD1-to-partner and partner-to-LMBRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMS grouped by LMBRD1-low versus LMBRD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMBRD1→partner) and Y-score (partner→LMBRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMS →	+0.654	+2.860	.003	.001	3	3
READ	MIR3619 →	+1.045	+4.361	<.001	.006	3	3
UCEC	RNA5SP113 →	+0.225	+2.582	<.001	.004	3	3
UCEC	ALDOA →	+0.502	+2.263	<.001	<.001	3	2
UCEC	QDPR →	+0.389	+2.280	.004	<.001	3	2
UCEC	ATP5F1A →	+0.438	+2.577	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,833 associations by consensus.

TYMS by LMBRD1 expression — UCEC

Explore this box plot interactively →