LMBRD1

Across TCGA cell cohorts, LMBRD1 mutation is significantly associated with the RNA expression of many other genes, with 863 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMBRD1-associated genes across cancer lineages are H2BC8, NAT8B, and EIF3L. Each is linked with LMBRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMBRD1-to-partner and partner-to-LMBRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC8 grouped by LMBRD1-low versus LMBRD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMBRD1→partner) and Y-score (partner→LMBRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H2BC8 →	-1.047	-2.541	<.001	.005	3	2
CNS	NAT8B →	+0.071	+4.981	<.001	.008	3	1
LARGE_INTESTINE	EIF3L →	+0.547	+3.389	<.001	.001	3	1
LARGE_INTESTINE	CCDC134 →	+0.772	+3.453	<.001	.001	3	1
LARGE_INTESTINE	CBY1 →	+0.630	+3.459	<.001	.001	3	1
LARGE_INTESTINE	JOSD1 →	+0.463	+3.169	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 863 associations by consensus.

H2BC8 by LMBRD1 expression — LARGE_INTESTINE

Explore this box plot interactively →