LMBR1L

Across TCGA pan-cancer cohorts, LMBR1L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LMBR1L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LMBR1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LMBR1L is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where LMBR1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LMBR1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.129	<.001	11	view →
THCA	All	II,III,IV	+0.484	<.001	8	view →
LIHC	Female	II,III,IV	+0.744	<.001	7	view →
KICH	Female	All	−0.890	<.001	6	view →
KIRP	All	All	+0.460	.007	6	view →
COAD	All	II,III,IV	+0.322	<.001	6	view →
CHOL	All	All	+1.782	<.001	5	view →
LUAD	Male	II,III,IV	+0.537	.007	4	view →
HNSC	Female	III,IV	+0.454	.004	4	view →
BRCA	Female	All	−0.259	<.001	4	view →
ESCA	All	All	+0.719	.022	2	view →
READ	All	All	+0.320	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LMBR1L–KIRC

Open the KIRC breakdown →