LMAN2L

Across TCGA patient cohorts, LMAN2L mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMAN2L-associated genes across cancer lineages are ETS-1, FoxM1, and p27_pT198. Each is linked with LMAN2L in more than 1 cancer types. Because this analysis shows association rather than direction, both LMAN2L-to-partner and partner-to-LMAN2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETS-1 grouped by LMAN2L-low versus LMAN2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMAN2L→partner) and Y-score (partner→LMAN2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ETS-1 →	-0.321	-2.115	.020	.019	3	1
UCEC	FoxM1 →	+0.263	+3.331	.020	.005	3	1
UCEC	p27_pT198 →	+0.103	+2.807	.027	.003	3	1
UCEC	Rad50 →	-0.237	-2.115	.025	.019	2	2
UCEC	Bax →	-0.222	-2.115	.034	.019	3	1
UCEC	Rab11 →	-0.143	-2.807	.024	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ETS-1 by LMAN2L expression — UCEC

Explore this box plot interactively →