LMAN2

Across TCGA patient cohorts, LMAN2 mutation is significantly associated with the RNA expression of many other genes, with 766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMAN2-associated genes across cancer lineages are RNU6-223P, MIR30C1, and NF1P6. Each is linked with LMAN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMAN2-to-partner and partner-to-LMAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-223P grouped by LMAN2-low versus LMAN2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMAN2→partner) and Y-score (partner→LMAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-223P →	+0.333	+4.969	<.001	.004	3	2
CESC	MIR30C1 →	+0.632	+5.507	<.001	<.001	3	2
CESC	NF1P6 →	+0.071	+5.342	.004	.002	3	2
CESC	SRSF1P1 →	+0.081	+5.144	<.001	.003	3	2
BRCA	RNU6-546P →	+0.181	+7.471	<.001	.008	3	2
BRCA	RNU6-938P →	+0.560	+5.646	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 766 associations by consensus.

RNU6-223P by LMAN2 expression — CESC

Explore this box plot interactively →