LMAN2

Across TCGA patient cohorts, LMAN2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMAN2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and eIF4E. Each is linked with LMAN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMAN2-to-partner and partner-to-LMAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LMAN2-low versus LMAN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMAN2→partner) and Y-score (partner→LMAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.911	+2.720	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.239	-1.807	.021	.027	3	1
UCEC	eIF4E →	+0.188	+2.584	.030	.010	3	1
UCEC	MEK1 →	+0.356	+1.807	.018	.027	3	1
UCEC	mTOR_pS2448 →	-0.138	-3.156	.024	.018	3	1
UCEC	Notch1 →	+0.141	+1.807	.015	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-7-cleavedD198 by LMAN2 expression — UCEC

Explore this box plot interactively →