LMAN1

Across TCGA pan-cancer cohorts, LMAN1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LMAN1 data layer compared with 29 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher LMAN1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LMAN1 expression acts as an unfavorable survival marker.

LUSC, LUAD, and UCEC are the cancer types where LMAN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	36	view →
LUAD	OS	Median	II,III,IV	0.017	0.710	<.001	15	view →
UCEC	DFS	Median	All	0.458	0.647	.032	8	view →
BLCA	OS	Median	III,IV	0.117	0.684	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LMAN1–LUSC (DFS)

Open the LUSC breakdown →