LMAN1

Across TCGA patient cohorts, LMAN1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMAN1-associated genes across cancer lineages are Caspase-8, DJ-1, and 14-3-3_beta. Each is linked with LMAN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMAN1-to-partner and partner-to-LMAN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by LMAN1-low versus LMAN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMAN1→partner) and Y-score (partner→LMAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.259	-2.973	.003	<.001	3	2
UCEC	DJ-1 →	+0.120	+1.887	.040	.029	3	2
UCEC	14-3-3_beta →	-0.085	-3.432	.016	.005	3	1
UCEC	eIF4E →	+0.187	+1.662	.011	.011	3	1
UCEC	ERK2 →	+0.155	+1.584	.022	.034	3	1
UCEC	Fibronectin →	-0.243	-2.105	.037	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-8 by LMAN1 expression — UCEC

Explore this box plot interactively →