LMAN1

Across TCGA cell cohorts, LMAN1 mutation is significantly associated with the RNA expression of many other genes, with 1,670 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMAN1-associated genes across cancer lineages are FGF23, XAGE5, and TOP3B. Each is linked with LMAN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMAN1-to-partner and partner-to-LMAN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF23 grouped by LMAN1-low versus LMAN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMAN1→partner) and Y-score (partner→LMAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FGF23 →	+0.274	+2.169	.009	.004	3	2
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
LARGE_INTESTINE	TOP3B →	+0.682	+3.169	.002	.009	3	1
LARGE_INTESTINE	GGA1 →	+0.705	+3.584	<.001	<.001	3	1
LARGE_INTESTINE	HIRA →	+0.640	+2.043	.003	.008	3	1
LARGE_INTESTINE	EIF3L →	+0.548	+3.389	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,670 associations by consensus.

FGF23 by LMAN1 expression — LARGE_INTESTINE

Explore this box plot interactively →