LLPH

Across TCGA pan-cancer cohorts, LLPH mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LLPH data layer compared with 25 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LLPH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LLPH expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where LLPH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.868	0.530	.011	16	view →
LUAD	DFS	Median	II,III,IV	0.218	0.792	.003	12	view →
CCRCC	DFS	Median	III,IV	0.401	0.732	.005	12	view →
PDAC	OS	Quartile	II,III,IV	0.362	0.674	.016	11	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LLPH–LSCC (DFS)

Open the LSCC breakdown →