LLPH

Across TCGA patient cohorts, LLPH mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LLPH-associated genes across cancer lineages are MIR6750, RNU7-107P, and RNU7-176P. Each is linked with LLPH in more than 1 cancer types. Because this analysis shows association rather than direction, both LLPH-to-partner and partner-to-LLPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6750 grouped by LLPH-low versus LLPH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LLPH→partner) and Y-score (partner→LLPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6750 →	+0.724	+2.561	<.001	.006	3	1
SKCM	RNU7-107P →	+0.507	+7.816	<.001	.008	3	1
COAD	RNU7-176P →	+0.537	+7.741	<.001	.009	3	1
UCEC	IER3IP1 →	+0.603	+3.223	.008	.009	3	1
UCEC	IL21 →	+0.156	+3.249	.002	<.001	3	1
UCEC	RNU6-582P →	+0.261	+4.245	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MIR6750 by LLPH expression — UCEC

Explore this box plot interactively →