LLPH

Across TCGA patient cohorts, LLPH mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LLPH-associated genes across cancer lineages are PDCD4, Rad50, and Bcl-xL. Each is linked with LLPH in more than 1 cancer types. Because this analysis shows association rather than direction, both LLPH-to-partner and partner-to-LLPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by LLPH-low versus LLPH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LLPH→partner) and Y-score (partner→LLPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.539	-3.000	.047	.037	3	1
UCEC	Rad50 →	-0.351	-3.000	.012	.037	3	1
UCEC	Bcl-xL →	+0.185	+3.000	.045	.037	3	1
UCEC	MIG-6 →	+0.166	+3.013	.003	.019	2	1
UCEC	mTOR_pS2448 →	-0.251	-3.000	.003	.037	1	1
UCEC	Notch1 →	+0.210	+3.000	.010	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PDCD4 by LLPH expression — UCEC

Explore this box plot interactively →