LLPH

Across TCGA cell cohorts, LLPH RNA expression is significantly associated with the go_rna of many other GO terms, with 2,998 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LLPH-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and RNA 5'-end processing. Each is linked with LLPH in more than 13 cancer types. Because this analysis shows association rather than direction, both LLPH-to-partner and partner-to-LLPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by LLPH-low versus LLPH-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LLPH→partner) and Y-score (partner→LLPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	rRNA 5'-end processing →	+0.128	+0.696	.007	<.001	2	14
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.128	+0.696	.007	<.001	2	14
UPPER_AERODIGESTIVE_TRACT	RNA 5'-end processing →	+0.093	+0.780	.002	.006	2	13
OVARY	Maturation of 5.8S rRNA →	+0.083	+0.575	.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell cycle checkpoint →	+0.117	+0.767	.002	.004	3	11
BLOOD_Myeloma	Maturation of SSU-rRNA →	+0.101	+0.739	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,998 associations by consensus.

rRNA 5'-end processing by LLPH expression — LIVER

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