LLGL2

Across TCGA patient cohorts, LLGL2 mutation is significantly associated with the RNA expression of many other genes, with 3,559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LLGL2-associated genes across cancer lineages are MIR4510, LEO1, and ZNF232. Each is linked with LLGL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LLGL2-to-partner and partner-to-LLGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by LLGL2-low versus LLGL2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LLGL2→partner) and Y-score (partner→LLGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4510 →	+0.195	+4.342	<.001	.007	3	3
UCEC	LEO1 →	+0.487	+3.839	<.001	<.001	3	3
UCEC	ZNF232 →	+0.478	+3.849	.002	<.001	3	3
UCEC	ESCO2 →	+0.618	+2.917	<.001	<.001	3	3
UCEC	ZNF543 →	+0.411	+2.081	.004	.001	3	3
UCEC	DEPDC1 →	+0.568	+2.949	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,559 associations by consensus.

MIR4510 by LLGL2 expression — CESC

Explore this box plot interactively →