LLGL2

Across TCGA patient cohorts, LLGL2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LLGL2-associated genes across cancer lineages are C-Raf, p38-MAPK_pT180_Y182, and Rab11. Each is linked with LLGL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LLGL2-to-partner and partner-to-LLGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by LLGL2-low versus LLGL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LLGL2→partner) and Y-score (partner→LLGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.187	+2.584	<.001	.010	3	3
SKCM	p38-MAPK_pT180_Y182 →	-0.324	-1.247	.006	.043	3	2
SKCM	Rab11 →	-0.150	-2.906	.030	.001	3	2
SKCM	Beclin →	-0.136	-2.000	.012	.027	3	2
UCEC	Cyclin-B1 →	+0.518	+2.459	.018	.019	3	2
UCEC	p62 Lck ligand →	+0.351	+3.469	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

C-Raf by LLGL2 expression — UCEC

Explore this box plot interactively →