LKAAEAR1

Across TCGA patient cohorts, LKAAEAR1 RNA expression is significantly associated with the mutation status of many other genes, with 7,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LKAAEAR1-associated genes across cancer lineages are TP53, DPP6, and ADGRG7. Each is linked with LKAAEAR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LKAAEAR1-to-partner and partner-to-LKAAEAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by LKAAEAR1-low versus LKAAEAR1-high in LGG.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LKAAEAR1→partner) and Y-score (partner→LKAAEAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	TP53 →	-0.928	-0.286	<.001	<.001	3	4
UCEC	DPP6 →	-1.584	-0.614	<.001	<.001	3	3
UCEC	ADGRG7 →	-2.544	-0.770	<.001	<.001	3	3
UCEC	EPHB1 →	-1.337	-0.446	<.001	.003	3	3
UCEC	TTN →	-0.573	-0.284	<.001	.006	3	3
UCEC	SVEP1 →	-1.759	-0.435	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,714 associations by consensus.

TP53 by LKAAEAR1 expression — LGG

Explore this box plot interactively →