LIX1L

Across TCGA patient cohorts, LIX1L mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIX1L-associated genes across cancer lineages are MIR3661, RNU6-1214P, and RNA5SP198. Each is linked with LIX1L in more than 1 cancer types. Because this analysis shows association rather than direction, both LIX1L-to-partner and partner-to-LIX1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3661 grouped by LIX1L-low versus LIX1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIX1L→partner) and Y-score (partner→LIX1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3661 →	+0.823	+3.699	.007	.004	3	2
CESC	RNU6-1214P →	+0.425	+5.306	<.001	.006	3	1
CESC	RNA5SP198 →	+0.384	+6.144	<.001	.001	3	1
CESC	GSTA6P →	+0.093	+5.010	.001	.009	3	1
CESC	RPL17P49 →	+0.136	+6.342	<.001	.001	3	1
CESC	PNPT1P2 →	+0.028	+5.306	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

MIR3661 by LIX1L expression — UCEC

Explore this box plot interactively →