LIX1L

Across TCGA cell cohorts, LIX1L mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LIX1L-associated genes across cancer lineages are TCF21, APOL5, and VRTN. Each is linked with LIX1L in more than 1 cancer types. Because this analysis shows association rather than direction, both LIX1L-to-partner and partner-to-LIX1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF21 grouped by LIX1L-low versus LIX1L-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIX1L→partner) and Y-score (partner→LIX1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCF21 →	+0.010	+3.705	<.001	.007	3	1
BLOOD_Leukemia	APOL5 →	+0.012	+4.060	.002	.003	3	1
BLOOD_Leukemia	VRTN →	+0.029	+4.339	.006	.002	3	1
BLOOD_Leukemia	TSHB →	+0.229	+4.691	<.001	<.001	3	1
BLOOD_Leukemia	RIPPLY1 →	+0.031	+4.269	<.001	.002	3	1
BLOOD_Leukemia	LRIT1 →	+0.043	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TCF21 by LIX1L expression — BLOOD_Leukemia

Explore this box plot interactively →