Across TCGA patient cohorts, LITAF mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LITAF-associated genes across cancer lineages are EGFR_pY1173, eIF4G, and FoxM1. Each is linked with LITAF in more than 1 cancer types. Because this analysis shows association rather than direction, both LITAF-to-partner and partner-to-LITAF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LITAF→partner) and Y-score (partner→LITAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.115	+2.827	.006	.035	3	1
UCEC	eIF4G →	+0.447	+3.321	.005	.010	3	1
UCEC	FoxM1 →	+0.268	+3.321	.048	.010	3	1
UCEC	Ku80 →	+0.383	+3.013	.001	.018	3	1
UCEC	Cyclin-E2 →	+0.308	+3.321	<.001	.010	3	1
UCEC	SF2 →	+0.116	+2.817	.044	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

LITAF survival (RNA) · tumor vs normal (RNA) · all LITAF data types