LIPT2

Across TCGA patient cohorts, LIPT2 mutation is significantly associated with the RNA expression of many other genes, with 612 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPT2-associated genes across cancer lineages are BTBD10, C11orf49, and TIRAP. Each is linked with LIPT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPT2-to-partner and partner-to-LIPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTBD10 grouped by LIPT2-low versus LIPT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPT2→partner) and Y-score (partner→LIPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTBD10 →	+0.565	+2.627	.003	.006	3	1
UCEC	C11orf49 →	+0.481	+3.337	.006	.005	3	1
UCEC	TIRAP →	+0.572	+3.346	.002	.005	3	1
UCEC	DLAT →	+0.645	+3.700	.005	.001	3	1
UCEC	NCAPD3 →	+0.837	+3.329	<.001	.005	3	1
UCEC	CENPU →	+0.951	+3.732	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 612 associations by consensus.

BTBD10 by LIPT2 expression — UCEC

Explore this box plot interactively →