LIPT2

Across TCGA patient cohorts, LIPT2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPT2-associated genes across cancer lineages are mTOR_pS2448, eIF4G, and ACC1. Each is linked with LIPT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPT2-to-partner and partner-to-LIPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by LIPT2-low versus LIPT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPT2→partner) and Y-score (partner→LIPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.159	-3.150	.027	.019	3	2
UCEC	eIF4G →	+0.317	+2.459	.034	.020	3	1
UCEC	ACC1 →	+0.413	+3.000	.018	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.221	-3.169	.006	.019	3	1
UCEC	JNK2 →	+0.272	+3.009	.004	.019	3	1
UCEC	Ku80 →	+0.348	+3.598	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

mTOR_pS2448 by LIPT2 expression — UCEC

Explore this box plot interactively →