LIPT1

Across TCGA patient cohorts, LIPT1 mutation is significantly associated with the RNA expression of many other genes, with 394 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPT1-associated genes across cancer lineages are OR1D5, KRTAP17-1, and LINC01014. Each is linked with LIPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPT1-to-partner and partner-to-LIPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1D5 grouped by LIPT1-low versus LIPT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPT1→partner) and Y-score (partner→LIPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR1D5 →	+0.049	+5.122	<.001	.004	3	2
COAD	KRTAP17-1 →	+0.475	+5.037	<.001	.002	3	1
COAD	LINC01014 →	+0.469	+4.324	<.001	.007	3	1
COAD	MTND5P27 →	+0.143	+5.917	<.001	.001	3	1
COAD	OFD1P6Y →	+0.011	+5.122	<.001	.004	3	1
COAD	TEMN3-AS1 →	+0.110	+5.917	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 394 associations by consensus.

OR1D5 by LIPT1 expression — COAD

Explore this box plot interactively →