LIPT1

Across TCGA patient cohorts, LIPT1 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPT1-associated genes across cancer lineages are p62 Lck ligand and Caspase-7-cleavedD198. Each is linked with LIPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPT1-to-partner and partner-to-LIPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by LIPT1-low versus LIPT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPT1→partner) and Y-score (partner→LIPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.607	+3.009	<.001	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.925	+2.827	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

p62 Lck ligand by LIPT1 expression — UCEC

Explore this box plot interactively →