Across TCGA patient cohorts, LIPN mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPN-associated genes across cancer lineages are MEP, CD4+ Tcm, and CD4+ Tem. Each is linked with LIPN in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPN-to-partner and partner-to-LIPN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPN→partner) and Y-score (partner→LIPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MEP →	+0.035	+2.826	.026	.035	3	2
HNSC	CD4+ Tcm →	+0.016	+5.468	<.001	.043	3	2
HNSC	CD4+ Tem →	+0.032	+6.623	<.001	.019	3	1
UCEC	Macrophages M2 →	+0.010	+2.921	.039	.030	3	1
UCEC	NKT →	-0.134	-3.435	.007	.005	2	1
SKCM	Erythrocytes →	+0.041	+3.006	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

LIPN survival (RNA) · tumor vs normal (RNA) · all LIPN data types