Across TCGA patient cohorts, LIPI mutation is significantly associated with the RNA expression of many other genes, with 3,895 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPI-associated genes across cancer lineages are PSMD9, RFC5, and CCT5. Each is linked with LIPI in more than 2 cancer types. Because this analysis shows association rather than direction, both LIPI-to-partner and partner-to-LIPI results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPI→partner) and Y-score (partner→LIPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD9 →	+0.359	+2.431	.001	.001	3	3
UCEC	RFC5 →	+0.575	+2.423	<.001	.001	3	3
UCEC	CCT5 →	+0.486	+2.376	.004	.002	3	3
LIHC	H2AZP5 →	+0.111	+5.033	.001	.009	3	2
READ	APOOP2 →	+0.655	+5.039	<.001	.008	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,895 associations by consensus.

Exploration

LIPI survival (RNA) · tumor vs normal (RNA) · all LIPI data types