LIPI

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, LIPI RNA expression is significantly associated with the go_rna of many other GO terms, with 3,460 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LIPI-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled, and Regulation of termination of RNA polymerase II transcription. Each is linked with LIPI in more than 7 cancer types. Because this analysis shows association rather than direction, both LIPI-to-partner and partner-to-LIPI results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPI→partner) and Y-score (partner→LIPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BONEPositive regulation of DNA repair →+0.072+3.197<.001<.00138
BONEPositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled →+0.143+3.995<.001<.00138
LUNG_SCLCRegulation of termination of RNA polymerase II transcription →+0.145+0.089.001.00138
LUNG_SCLCRegulation of termination of RNA polymerase II transcription, poly(A)-coupled →+0.141+0.097.001<.00138
LUNG_SCLCRegulation of termination of DNA-templated transcription →+0.145+0.089.001.00138
BONEProtein-DNA complex organization →+0.077+3.508<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,460 associations by consensus.

Exploration