LIPG

Across TCGA patient cohorts, LIPG mutation is significantly associated with the RNA expression of many other genes, with 3,217 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPG-associated genes across cancer lineages are RNA5SP248, TRAJ42, and RN7SKP286. Each is linked with LIPG in more than 2 cancer types. Because this analysis shows association rather than direction, both LIPG-to-partner and partner-to-LIPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP248 grouped by LIPG-low versus LIPG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPG→partner) and Y-score (partner→LIPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP248 →	+0.338	+1.919	<.001	.003	3	3
UCEC	TRAJ42 →	+0.664	+2.592	<.001	<.001	3	3
UCEC	RN7SKP286 →	+0.035	+3.812	<.001	.008	3	3
UCEC	SKA1 →	+0.818	+3.258	<.001	<.001	3	2
UCEC	EME1 →	+0.604	+2.595	.001	<.001	3	2
UCEC	SUPV3L1 →	+0.432	+4.332	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,217 associations by consensus.

RNA5SP248 by LIPG expression — UCEC

Explore this box plot interactively →