LIPF

Across TCGA patient cohorts, LIPF RNA expression is significantly associated with the go_rna of many other GO terms, with 5,974 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPF-associated GO terms across cancer lineages are Negative regulation of Wnt signaling pathway, Regulation of stress-activated protein kinase signaling cascade, and Negative regulation of canonical Wnt signaling pathway. Each is linked with LIPF in more than 6 cancer types. Because this analysis shows association rather than direction, both LIPF-to-partner and partner-to-LIPF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Wnt signaling pathway grouped by LIPF-low versus LIPF-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPF→partner) and Y-score (partner→LIPF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Negative regulation of Wnt signaling pathway →	+0.045	+0.175	<.001	.001	3	7
LAML	Regulation of stress-activated protein kinase signaling cascade →	+0.023	+0.086	.001	.001	3	6
TGCT	Negative regulation of canonical Wnt signaling pathway →	+0.045	+0.178	<.001	.002	3	6
LAML	Autophagy of mitochondrion →	+0.028	+0.083	<.001	<.001	3	6
TGCT	Protein stabilization →	+0.025	+0.147	<.001	<.001	2	6
UCEC	Import into nucleus →	+0.030	+0.172	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,974 associations by consensus.

Negative regulation of Wnt signaling pathway by LIPF expression — TGCT

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