LIPF

Across TCGA patient cohorts, LIPF mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPF-associated genes across cancer lineages are TFRC, Rab25, and Fibronectin. Each is linked with LIPF in more than 2 cancer types. Because this analysis shows association rather than direction, both LIPF-to-partner and partner-to-LIPF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by LIPF-low versus LIPF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPF→partner) and Y-score (partner→LIPF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.538	+1.584	.009	.036	3	3
UCEC	Rab25 →	-0.271	-3.321	.037	.010	3	2
SKCM	Fibronectin →	+0.642	+3.000	.012	.036	3	1
UCEC	EGFR_pY1068 →	-0.232	-2.459	.018	.019	3	1
UCEC	Ku80 →	+0.189	+2.013	.042	.005	3	1
UCEC	NF-kB-p65_pS536 →	-0.384	-2.999	.031	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

TFRC by LIPF expression — UCEC

Explore this box plot interactively →