LIPA

Across TCGA pan-cancer cohorts, LIPA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LIPA data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LIPA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LIPA expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where LIPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.673	0.899	.002	51	view →
UCEC	DFS	Tertile	II,III,IV	0.425	0.904	.018	12	view →
CCRCC	DFS	Quartile	All	0.963	0.770	.011	8	view →
PDAC	OS	Tertile	IV	0.231	0.962	.024	3	view →
LUAD	DFS	Median	II,III,IV	0.640	0.378	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LIPA–HNSC (DFS)

Open the HNSC breakdown →