LIPA

Across TCGA patient cohorts, LIPA protein abundance is significantly associated with the RNA expression of many other genes, with 10,521 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LIPA-associated genes across cancer lineages are PKD2L1, HTRA4, and ACP5. Each is linked with LIPA in more than 7 cancer types. Because this analysis shows association rather than direction, both LIPA-to-partner and partner-to-LIPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIPA versus PKD2L1 in CCRCC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPA→partner) and Y-score (partner→LIPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PKD2L1 →	+0.827	+0.520	<.001	<.001	3	8
CCRCC	HTRA4 →	+1.046	+0.482	<.001	<.001	3	8
CCRCC	ACP5 →	+1.356	+0.536	<.001	<.001	3	7
HNSC	APOC1 →	+1.751	+0.478	<.001	<.001	3	7
GBM	DPEP2 →	+0.773	+0.603	<.001	<.001	3	7
UCEC	BIN2 →	+0.732	+0.390	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,521 associations by consensus.

LIPA vs PKD2L1 — CCRCC

Explore this scatter interactively →