LIPA

Across TCGA patient cohorts, LIPA mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPA-associated genes across cancer lineages are EGFR_pY1173, eIF4E, and Gab2. Each is linked with LIPA in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPA-to-partner and partner-to-LIPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by LIPA-low versus LIPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPA→partner) and Y-score (partner→LIPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.080	+2.026	.026	.018	3	1
UCEC	eIF4E →	+0.203	+3.169	.033	.019	3	1
UCEC	Gab2 →	+0.583	+3.321	<.001	.010	3	1
UCEC	NDRG1_pT346 →	-0.550	-2.700	.012	.006	3	1
UCEC	Notch1 →	+0.239	+3.335	<.001	.005	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.653	-3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1173 by LIPA expression — UCEC

Explore this box plot interactively →