LIPA

Across TCGA cell cohorts, LIPA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,820 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LIPA-associated GO terms across cancer lineages are Glycolipid catabolic process, Antigen processing and presentation of peptide antigen via MHC class I, and Antigen processing and presentation. Each is linked with LIPA in more than 10 cancer types. Because this analysis shows association rather than direction, both LIPA-to-partner and partner-to-LIPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycolipid catabolic process grouped by LIPA-low versus LIPA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPA→partner) and Y-score (partner→LIPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Glycolipid catabolic process →	+0.160	+1.242	.002	<.001	3	11
LUNG_SCLC	Antigen processing and presentation of peptide antigen via MHC class I →	+0.183	+1.466	<.001	<.001	3	10
BONE	Antigen processing and presentation →	+0.165	+1.353	<.001	<.001	3	9
BREAST	Type II interferon-mediated signaling pathway →	+0.163	+1.082	<.001	<.001	3	9
BONE	ER-nucleus signaling pathway →	+0.109	+1.380	.004	.001	3	9
LUNG_NSCLC_LUSC	Peptide catabolic process →	+0.198	+1.495	.004	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,820 associations by consensus.

Glycolipid catabolic process by LIPA expression — BONE

Explore this box plot interactively →