LINS1

Across TCGA patient cohorts, LINS1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINS1-associated genes across cancer lineages are EGFR_pY1068, GSK-3_pS9, and Acetyl-a-Tubulin-Lys40. Each is linked with LINS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINS1-to-partner and partner-to-LINS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LINS1-low versus LINS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINS1→partner) and Y-score (partner→LINS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.234	-2.115	.033	.019	3	1
UCEC	GSK-3_pS9 →	-0.420	-2.000	.017	.030	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.483	+2.179	.029	.034	3	1
UCEC	INPP4B →	-0.305	-3.169	.031	.018	3	1
UCEC	JNK2 →	+0.224	+2.331	.009	.019	3	1
UCEC	Ku80 →	+0.272	+2.820	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by LINS1 expression — UCEC

Explore this box plot interactively →