Across TCGA pan-cancer cohorts, LINP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LINP1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINP1 is over-expressed in tumor, although a few such as LIHC and BRCA show the opposite, repressed pattern.
KIRC, KIRP, and HNSC are the cancer types where LINP1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINP1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.