Across TCGA pan-cancer cohorts, LINGO4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LINGO4 data layer compared with 24 for mass-spec protein.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher LINGO4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LINGO4 expression acts as an unfavorable survival marker.
BLCA, UCEC, and HNSC are the cancer types where LINGO4 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.