Across TCGA patient cohorts, LINGO4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINGO4-associated genes across cancer lineages are ATM, A-Raf_pS299, and ERK2. Each is linked with LINGO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO4-to-partner and partner-to-LINGO4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO4→partner) and Y-score (partner→LINGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.676	-3.687	<.001	.001	3	2
UCEC	A-Raf_pS299 →	-0.125	-2.321	.009	.034	3	1
UCEC	ERK2 →	+0.167	+2.999	.031	.035	3	1
UCEC	Gab2 →	+0.300	+1.906	.036	.016	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.475	+3.321	.005	.009	3	1
UCEC	JNK2 →	+0.246	+3.348	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

LINGO4 survival (RNA) · tumor vs normal (RNA) · all LINGO4 data types