Across TCGA cell cohorts, LINGO4 RNA expression is significantly associated with the go_rna of many other GO terms, with 645 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LINGO4-associated GO terms across cancer lineages are Negative regulation of CD8-positive, alpha-beta T cell differentiation, Positive regulation of collagen biosynthetic process, and Negative regulation of NK T cell activation. Each is linked with LINGO4 in more than 4 cancer types. Because this analysis shows association rather than direction, both LINGO4-to-partner and partner-to-LINGO4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO4→partner) and Y-score (partner→LINGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of CD8-positive, alpha-beta T cell differentiation →	+0.243	+0.110	<.001	<.001	3	5
LUNG_SCLC	Positive regulation of collagen biosynthetic process →	-0.110	-0.098	.001	.002	3	5
LUNG_NSCLC_LUAD	Negative regulation of NK T cell activation →	+0.160	+0.149	<.001	.006	3	5
BREAST	Activation of GTPase activity →	+0.081	+0.163	.003	.007	3	4
BREAST	Membrane bending →	+0.165	+0.151	.003	<.001	2	5
BREAST	Fibrinolysis →	-1.404	-0.148	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

Exploration

LINGO4 survival (RNA) · tumor vs normal (RNA) · all LINGO4 data types