Across TCGA cell cohorts, LINGO4 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LINGO4-associated genes across cancer lineages are JNJ38877605, SU11274, and Gallibiscoquinazole. Each is linked with LINGO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO4-to-partner and partner-to-LINGO4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO4→partner) and Y-score (partner→LINGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JNJ38877605 →	+0.381	+3.008	.020	.016	3	1
LARGE_INTESTINE	SU11274 →	+0.492	+2.874	.011	.021	3	1
LARGE_INTESTINE	Gallibiscoquinazole →	+0.375	+2.871	.015	.021	2	1
LARGE_INTESTINE	L-Oxonoreleagnine →	+0.438	+3.000	.001	.017	2	1
LARGE_INTESTINE	729189 →	+0.282	+2.684	.019	.035	2	1
LARGE_INTESTINE	LY2109761 →	+0.390	+2.868	.013	.022	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

LINGO4 survival (RNA) · tumor vs normal (RNA) · all LINGO4 data types