Across TCGA pan-cancer cohorts, LINC02729 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC02729’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC02729 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02729 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.
HNSC are the cancer types where LINC02729 tumor–normal differential expression is most reproducible.