Across TCGA pan-cancer cohorts, LINC02505 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC02505’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC02505 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02505 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC, BRCA, and LUSC are the cancer types where LINC02505 tumor–normal differential expression is most reproducible.