Across TCGA pan-cancer cohorts, LINC02455 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC02455’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC02455 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02455 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
KIRC, STAD, and BLCA are the cancer types where LINC02455 tumor–normal differential expression is most reproducible.