LINC02454

Across TCGA pan-cancer cohorts, LINC02454 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LINC02454’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC02454 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02454 is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where LINC02454 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02454 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.985	<.001	12	view →
THCA	Male	III,IV	+3.045	<.001	11	view →
LUAD	All	II,III,IV	+0.541	<.001	7	view →
KIRP	All	All	+0.233	.017	6	view →
LUSC	Male	II,III,IV	+0.951	<.001	4	view →
BRCA	Female	All	−0.204	<.001	4	view →
KIRC	Male	All	+0.163	.001	4	view →
READ	Male	All	+0.370	.036	2	view →
PRAD	All	All	−0.108	<.001	2	view →
READ	Female	All	−0.378	.030	1	view →
COAD	Male	IV	+0.288	.038	1	view →
KICH	Female	All	−0.103	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LINC02454–HNSC

Open the HNSC breakdown →