LINC02447

Across TCGA pan-cancer cohorts, LINC02447 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LINC02447’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LINC02447 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02447 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and COAD are the cancer types where LINC02447 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02447 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.044	<.001	11	view →
KIRP	Male	III,IV	−0.815	<.001	11	view →
COAD	Female	II,III,IV	−0.321	<.001	11	view →
BLCA	Male	III,IV	−0.561	<.001	10	view →
KICH	Male	All	−0.860	<.001	9	view →
LUAD	Male	II,III,IV	−0.333	<.001	8	view →
BRCA	All	II,III,IV	−0.329	<.001	8	view →
UCEC	All	III,IV	−0.986	<.001	6	view →
LUSC	Male	III,IV	−0.652	<.001	6	view →
KIRC	Male	All	−0.415	<.001	6	view →
STAD	All	All	−0.202	.001	5	view →
READ	All	II,III,IV	−0.430	.009	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LINC02447–THCA

Open the THCA breakdown →